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Comprehensive and Computable Molecular Diagnostic Panel (C2Dx) From Small Volume Specimens for Precision Oncology: Molecular Subtyping of Non-Small Cell Lung Cancer From Fine Needle Aspirates.
Su, Jing; Huang, Lynn S; Barnard, Ryan; Parks, Graham; Cappellari, James; Bellinger, Christina; Dotson, Travis; Craddock, Lou; Prakash, Bharat; Hovda, Jonathan; Clark, Hollins; Petty, William Jeffrey; Pasche, Boris; Chan, Michael D; Miller, Lance D; Ruiz, Jimmy.
Afiliação
  • Su J; Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Huang LS; Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, United States.
  • Barnard R; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Parks G; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Cappellari J; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Bellinger C; Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Dotson T; Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Craddock L; Department of Medicine (Pulmonology and Critical Care), Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Prakash B; Department of Medicine (Pulmonology and Critical Care), Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Hovda J; Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Clark H; Department of Medicine (Pulmonology and Critical Care), Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Petty WJ; Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Pasche B; Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Chan MD; Department of Medicine (Hematology & Oncology), Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Miller LD; Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Ruiz J; Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Front Oncol ; 11: 584896, 2021.
Article em En | MEDLINE | ID: mdl-33937015
ABSTRACT
The Comprehensive, Computable NanoString Diagnostic gene panel (C2Dx) is a promising solution to address the need for a molecular pathological research and diagnostic tool for precision oncology utilizing small volume tumor specimens. We translate subtyping-related gene expression patterns of Non-Small Cell Lung Cancer (NSCLC) derived from public transcriptomic data which establish a highly robust and accurate subtyping system. The C2Dx demonstrates supreme performance on the NanoString platform using microgram-level FNA samples and has excellent portability to frozen tissues and RNA-Seq transcriptomic data. This workflow shows great potential for research and the clinical practice of cancer molecular diagnosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Front Oncol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Front Oncol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos