Direct and selective metal-free N6-arylation of adenosine residues for simple fluorescence labeling of DNA and RNA.
Chem Commun (Camb)
; 57(44): 5450-5453, 2021 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-33950062
ABSTRACT
We have developed an unprecedented transition metal-free approach for the direct fluorescence turn-on labeling of natural oligonucleotides through selective N6-arylation of adenosine moieties. This method allows the simple and direct fluorescence labeling of natural unmodified DNA and RNA, but is dependent on the secondary structure, favoring single-stranded structures.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
RNA
/
Adenosina
/
Fluorescência
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Coréia do Sul