From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation.

Cecchini, Carlotta; Pannilunghi, Sara; Tardy, Sébastien; Scapozza, Leonardo

Cecchini, Carlotta; Pannilunghi, Sara; Tardy, Sébastien; Scapozza, Leonardo.

Afiliação

Cecchini C; School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Pannilunghi S; Pharmaceutical Biochemistry/Chemistry, Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
Tardy S; School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Scapozza L; Pharmaceutical Biochemistry/Chemistry, Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.

Front Chem ; 9: 672267, 2021.

Article em En | MEDLINE | ID: mdl-33959589

Palavras-chave

PROTAC technology; cell permeability; drug discovery; protein degradation; proteolysis targeting chimeras; ubiquitin-proteasome system

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suíça

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