Asymmetric Reduction of Aromatic α-Dehydroamino Acid Esters with Water as Hydrogen Source.
J Org Chem
; 86(10): 7141-7147, 2021 05 21.
Article
em En
| MEDLINE
| ID: mdl-33966384
ABSTRACT
The asymmetric reduction of aromatic α-dehydroamino acid esters with water as the hydrogen source was developed by a Rh/Cu co-catalytic system. The reaction tolerates various functional groups, providing a valuable synthetic tool to access chiral α-amino acid esters readily. Moreover, the present methodology also was applied in the cost-effective and easy to handle preparation of chiral deuterated α-amino esters by using D2O.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Água
/
Ésteres
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China