Clinical development of bempedoic acid: phase 2 and phase 3 clinical trials. / Desarrollo clínico de ácido bempedoico: estudios fase 2 y fase 3.
Clin Investig Arterioscler
; 33 Suppl 1: 58-64, 2021 May.
Article
em En, Es
| MEDLINE
| ID: mdl-33966815
ABSTRACT
We review all the phase II and III studies carried out with bempedoic acid at the dose of 180mg, alone or in combination with different lipid-lowering drugs and in different subgroups of patients that unequivocally show the efficacy and safety of the drug. We point out some of the potential advantages of its use in clinical practice in patients with statin intolerance and the efficacy in reducing LDL-c when combined with statins, and with statins and ezetimibe, as well as in reducing inflammation markers pending the results of the CV Clear Outcomes trial that will end in 2022.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Dicarboxílicos
/
Ácidos Graxos
/
Hipercolesterolemia
/
Hipolipemiantes
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
/
Es
Revista:
Clin Investig Arterioscler
Ano de publicação:
2021
Tipo de documento:
Article