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Endogenous retroviruses in the origins and treatment of cancer.
Jansz, Natasha; Faulkner, Geoffrey J.
Afiliação
  • Jansz N; Mater Research Institute - University of Queensland, TRI Building, Woolloongabba, QLD, 4102, Australia. natasha.jansz@mater.uq.edu.au.
  • Faulkner GJ; Mater Research Institute - University of Queensland, TRI Building, Woolloongabba, QLD, 4102, Australia. faulknergj@gmail.com.
Genome Biol ; 22(1): 147, 2021 05 10.
Article em En | MEDLINE | ID: mdl-33971937
Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer. As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate expression from gene networks, including those underpinning embryogenesis and immune cell function. ERV activation can promote an interferon response, a phenomenon termed viral mimicry. Although ERV expression is associated with cancer, and provisionally with autoimmune and neurodegenerative diseases, ERV-mediated inflammation is being explored as a way to sensitize tumors to immunotherapy. Here we review ERV co-option in development and innate immunity, the aberrant contribution of ERVs to tumorigenesis, and the wider biomedical potential of therapies directed at ERVs.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retrovirus Endógenos / Neoplasias Limite: Animals / Humans Idioma: En Revista: Genome Biol Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Austrália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retrovirus Endógenos / Neoplasias Limite: Animals / Humans Idioma: En Revista: Genome Biol Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Austrália