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Common genetic variants associated with obesity in an African-American and Hispanic/Latino population.
Chalazan, Brandon; Palm, Denada; Sridhar, Arvind; Lee, Christina; Argos, Maria; Daviglus, Martha; Rehman, Jalees; Konda, Sreenivas; Darbar, Dawood.
Afiliação
  • Chalazan B; Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.
  • Palm D; Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.
  • Sridhar A; Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.
  • Lee C; Broad Institute of MIT and Harvard, Boston, Massachusetts, United States of America.
  • Argos M; Division of Epidemiology and Biostatics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois, United States of America.
  • Daviglus M; Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.
  • Rehman J; Institute for Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, United States of America.
  • Konda S; Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.
  • Darbar D; Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, United States of America.
PLoS One ; 16(5): e0250697, 2021.
Article em En | MEDLINE | ID: mdl-33983957
ABSTRACT

INTRODUCTION:

Over 35% of all adults in the world are currently obese and risk of obesity in racial or ethnic minority groups exist in the US, but the causes of these differences are not all known. As obesity is a leading cause of cardiovascular disease, an improved understanding of risk factors across racial and ethnic groups may improve outcomes.

OBJECTIVE:

The objective of this study was to determine if susceptibility to obesity is associated with genetic variation in candidate single nucleotide polymorphisms (SNPs) in African Americans and Hispanic/Latinos. MATERIALS AND

METHODS:

We examined data from 534 African Americans and 557 Hispanic/Latinos participants from the UIC Cohort of Patients, Family and Friends. Participants were genotyped for the top 26 obesity-associated SNPs within FTO, MC4R, TUB, APOA2, APOA5, ADIPOQ, ARL15, CDH13, KNG1, LEPR, leptin, and SCG3 genes.

RESULTS:

The mean (SD) age of participants was 49±13 years, 55% were female, and mean body mass index (BMI) was 31±7.5 kg/m2. After adjusting for age and sex, we found that rs8050136 in FTO (odds ratio [OR] 1.40, 95% confidence interval [CI] 1.1-1.8; P = 0.01) among African Americans and rs2272383 in TUB (OR 1.34, 95% CI 1.04-1.71; P = 0.02) among Hispanic/Latinos were associated with obesity. However, none of the SNPs in multivariable analysis of either AA or H/L cohorts were significant when adjusted for multiple correction.

CONCLUSIONS:

We show that candidate SNPs in the FTO and TUB genes are associated with obesity in African Americans and Hispanic/Latinos individuals respectively. While the underlying pathophysiological mechanisms by which common genetic variants cause obesity remain unclear, we have identified novel therapeutic targets across racial and ethnic groups.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Negro ou Afro-Americano / Hispânico ou Latino / Obesidade Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Negro ou Afro-Americano / Hispânico ou Latino / Obesidade Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos