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Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.
Rogawski, David S; Deng, Jing; Li, Hao; Miao, Hongzhi; Borkin, Dmitry; Purohit, Trupta; Song, Jiho; Chase, Jennifer; Li, Shuangjiang; Ndoj, Juliano; Klossowski, Szymon; Kim, EunGi; Mao, Fengbiao; Zhou, Bo; Ropa, James; Krotoska, Marta Z; Jin, Zhuang; Ernst, Patricia; Feng, Xiaomin; Huang, Gang; Nishioka, Kenichi; Kelly, Samantha; He, Miao; Wen, Bo; Sun, Duxin; Muntean, Andrew; Dou, Yali; Maillard, Ivan; Cierpicki, Tomasz; Grembecka, Jolanta.
Afiliação
  • Rogawski DS; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Deng J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Li H; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Miao H; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Borkin D; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Purohit T; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Song J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Chase J; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
  • Li S; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Ndoj J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Klossowski S; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Kim E; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Mao F; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Zhou B; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Ropa J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Krotoska MZ; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Jin Z; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Ernst P; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Feng X; Department of Pediatrics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
  • Huang G; Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital, Cincinnati, OH, USA.
  • Nishioka K; Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital, Cincinnati, OH, USA.
  • Kelly S; Department of Internal Medicine Musashimurayama Hospital, Enoki 1-1-5, Musashimurayama, Tokyo, Japan.
  • He M; Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Wen B; College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
  • Sun D; College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
  • Muntean A; College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
  • Dou Y; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Maillard I; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Cierpicki T; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
  • Grembecka J; Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nat Commun ; 12(1): 2792, 2021 05 14.
Article em En | MEDLINE | ID: mdl-33990599
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia / Histona-Lisina N-Metiltransferase / Proteínas de Ligação a DNA / Inibidores Enzimáticos / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia / Histona-Lisina N-Metiltransferase / Proteínas de Ligação a DNA / Inibidores Enzimáticos / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos