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Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial.
Bian, Huijie; Zheng, Zhao-Hui; Wei, Ding; Wen, Aidong; Zhang, Zheng; Lian, Jian-Qi; Kang, Wen-Zhen; Hao, Chun-Qiu; Wang, Jing; Xie, Rong-Hua; Dong, Ke; Xia, Jie-Lai; Miao, Jin-Lin; Kang, Wen; Li, Guoquan; Zhang, Di; Zhang, Mingru; Sun, Xiu-Xuan; Ding, Likun; Zhang, Kui; Jia, Junfeng; Ding, Jin; Li, Zhiqin; Jia, Yanyan; Liu, Lin-Na; Zhang, Zhe; Gao, Zhao-Wei; Du, Hong; Yao, Na; Wang, Qing; Wang, Ke; Geng, Jie-Jie; Wang, Bin; Guo, Ting; Chen, Ruo; Zhu, Yu-Meng; Wang, Li-Juan; He, Qian; Yao, Rui-Rui; Shi, Ying; Yang, Xiang-Min; Zhou, Jian-Sheng; Ma, Yi-Nan; Wang, Ya-Tao; Liang, Xue; Huo, Fei; Wang, Zhe; Zhang, Yang; Yang, Xu; Zhang, Ye.
Afiliação
  • Bian H; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China. hjbian@fmmu.edu.cn.
  • Zheng ZH; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Wei D; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Wen A; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Zhang Z; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Lian JQ; Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
  • Kang WZ; Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
  • Hao CQ; Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
  • Wang J; Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Xie RH; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Dong K; Department of Clinical Diagnosis, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
  • Xia JL; College of Military Preventive Medicine, Fourth Military Medical University, Xi'an, China.
  • Miao JL; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Kang W; Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
  • Li G; Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Zhang D; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Zhang M; Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Sun XX; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Ding L; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Zhang K; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Jia J; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Ding J; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Li Z; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Jia Y; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Liu LN; Department of Pharmaceutics, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
  • Zhang Z; Department of Clinical Diagnosis, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
  • Gao ZW; Department of Clinical Diagnosis, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
  • Du H; Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
  • Yao N; Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
  • Wang Q; Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Wang K; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Geng JJ; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Wang B; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Guo T; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Chen R; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Zhu YM; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Wang LJ; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • He Q; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Yao RR; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Shi Y; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Yang XM; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Zhou JS; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Ma YN; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Wang YT; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Liang X; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Huo F; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Wang Z; Department of Pathology, Fourth Military Medical University, Xi'an, China.
  • Zhang Y; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Yang X; National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, China.
  • Zhang Y; Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Signal Transduct Target Ther ; 6(1): 194, 2021 05 17.
Article em En | MEDLINE | ID: mdl-34001849
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Monoclonais Humanizados / SARS-CoV-2 / COVID-19 / Tratamento Farmacológico da COVID-19 / Pulmão Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Signal Transduct Target Ther Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Monoclonais Humanizados / SARS-CoV-2 / COVID-19 / Tratamento Farmacológico da COVID-19 / Pulmão Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Signal Transduct Target Ther Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China