Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry.
R Soc Open Sci
; 8(3): 201703, 2021 Mar 31.
Article
em En
| MEDLINE
| ID: mdl-34035937
ABSTRACT
Liquid-assisted mechanochemistry as a versatile approach for the coupling of a nucleoside phosphoramidite with a 5'-OH partially protected nucleoside has been investigated. Noted advantages over reported methods were a simplified reaction protocol, a drastic reduction in the use of toxic solvents, the facilitation of mechanochemical reactions through the improved mixing of solid reagents, and low hydrolytic product formation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
R Soc Open Sci
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Reino Unido