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Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the London mutation in APP (V717I).
Hernández, Damián; Morgan Schlicht, Stephanie; Daniszewski, Maciej; Karch, Celeste M; Goate, Alison M; Pébay, Alice.
Afiliação
  • Hernández D; Department of Anatomy and Physiology, the University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: damian.hernandez@unimelb.edu.au.
  • Morgan Schlicht S; Department of Anatomy and Physiology, the University of Melbourne, Parkville, VIC 3010, Australia.
  • Daniszewski M; Department of Anatomy and Physiology, the University of Melbourne, Parkville, VIC 3010, Australia.
  • Karch CM; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Goate AM; Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.
  • Pébay A; Department of Anatomy and Physiology, the University of Melbourne, Parkville, VIC 3010, Australia; Department of Surgery, Royal Melbourne Hospital, the University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: apebay@unimelb.edu.au.
Stem Cell Res ; 53: 102373, 2021 05.
Article em En | MEDLINE | ID: mdl-34088002
ABSTRACT
We report the genome-editing of an existing iPSC line carrying the London mutation in APP (V717I) into an iPSC line in which the pathogenic mutation was corrected. The resulting isogenic iPSC line maintained pluripotent stem cell morphology, a normal karyotype, expression of pluripotency markers and the ability to differentiate into the three germ-layers in vitro.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas / Doença de Alzheimer Limite: Humans País/Região como assunto: Europa Idioma: En Revista: Stem Cell Res Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas / Doença de Alzheimer Limite: Humans País/Região como assunto: Europa Idioma: En Revista: Stem Cell Res Ano de publicação: 2021 Tipo de documento: Article