Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome <i>In Vitro</i> by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling.

Wurzer, Hannah; Filali, Liza; Hoffmann, Céline; Krecke, Max; Biolato, Andrea Michela; Mastio, Jérôme; De Wilde, Sigrid; François, Jean Hugues; Largeot, Anne; Berchem, Guy; Paggetti, Jérôme; Moussay, Etienne; Thomas, Clément

Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling.

Wurzer, Hannah; Filali, Liza; Hoffmann, Céline; Krecke, Max; Biolato, Andrea Michela; Mastio, Jérôme; De Wilde, Sigrid; François, Jean Hugues; Largeot, Anne; Berchem, Guy; Paggetti, Jérôme; Moussay, Etienne; Thomas, Clément.

Afiliação

Wurzer H; Cytoskeleton and Cancer Progression, Department of Oncology, Luxembourg Institute of Health, Luxembourg City, Luxembourg.
Filali L; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Hoffmann C; Cytoskeleton and Cancer Progression, Department of Oncology, Luxembourg Institute of Health, Luxembourg City, Luxembourg.
Krecke M; Cytoskeleton and Cancer Progression, Department of Oncology, Luxembourg Institute of Health, Luxembourg City, Luxembourg.
Biolato AM; Cytoskeleton and Cancer Progression, Department of Oncology, Luxembourg Institute of Health, Luxembourg City, Luxembourg.
Mastio J; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
De Wilde S; Cytoskeleton and Cancer Progression, Department of Oncology, Luxembourg Institute of Health, Luxembourg City, Luxembourg.
François JH; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Largeot A; Cytoskeleton and Cancer Progression, Department of Oncology, Luxembourg Institute of Health, Luxembourg City, Luxembourg.
Berchem G; Department of Hemato-Oncology, Central Hospitalier du Luxembourg, Luxembourg City, Luxembourg.
Paggetti J; Laboratory of Hematology, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg.
Moussay E; Tumor-Stroma Interactions, Department of Oncology, Luxembourg Institute of Health, Luxembourg City, Luxembourg.
Thomas C; Department of Hemato-Oncology, Central Hospitalier du Luxembourg, Luxembourg City, Luxembourg.

Front Immunol ; 12: 619069, 2021.

Article em En | MEDLINE | ID: mdl-34108958

Assuntos

Citoesqueleto de Actina/metabolismo; Citotoxicidade Imunológica; Células Matadoras Naturais/imunologia; Células Matadoras Naturais/metabolismo; Leucemia Linfocítica Crônica de Células B/imunologia; Leucemia Linfocítica Crônica de Células B/metabolismo; Proteína cdc42 de Ligação ao GTP/antagonistas & inibidores; Citoesqueleto de Actina/efeitos dos fármacos; Biomarcadores; Linhagem Celular Tumoral; Citotoxicidade Imunológica/efeitos dos fármacos; Imunofluorescência; Antígenos HLA-G/imunologia; Humanos; Sinapses Imunológicas/imunologia; Sinapses Imunológicas/metabolismo; Imunofenotipagem; Células Matadoras Naturais/efeitos dos fármacos; Leucemia Linfocítica Crônica de Células B/tratamento farmacológico; Leucemia Linfocítica Crônica de Células B/patologia; Microambiente Tumoral/genética; Microambiente Tumoral/imunologia

Palavras-chave

B cell neoplasms; Cdc42; actin cytoskeleton; immune evasion; immunological synapse; natural killer (NK); tumor immunology

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citoesqueleto de Actina / Células Matadoras Naturais / Leucemia Linfocítica Crônica de Células B / Proteína cdc42 de Ligação ao GTP / Citotoxicidade Imunológica Limite: Humans Idioma: En Revista: Front Immunol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Luxemburgo

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google