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Migraine and neuroinflammation: the inflammasome perspective.
Kursun, Oguzhan; Yemisci, Muge; van den Maagdenberg, Arn M J M; Karatas, Hulya.
Afiliação
  • Kursun O; Department of Neurology, City Hospital, Ankara, Turkey.
  • Yemisci M; Institute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey.
  • van den Maagdenberg AMJM; Department of Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Karatas H; Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
J Headache Pain ; 22(1): 55, 2021 Jun 10.
Article em En | MEDLINE | ID: mdl-34112082
ABSTRACT

BACKGROUND:

Neuroinflammation has an important role in the pathophysiology of migraine, which is a complex neuro-glio-vascular disorder. The main aim of this review is to highlight findings of cortical spreading depolarization (CSD)-induced neuroinflammatory signaling in brain parenchyma from the inflammasome perspective. In addition, we discuss the limited data of the contribution of inflammasomes to other aspects of migraine pathophysiology, foremost the activation of the trigeminovascular system and thereby the generation of migraine pain. MAIN BODY Inflammasomes are signaling multiprotein complexes and key components of the innate immune system. Their activation causes the production of inflammatory cytokines that can stimulate trigeminal neurons and are thus relevant to the generation of migraine pain. The contribution of inflammasome activation to pain signaling has attracted considerable attention in recent years. Nucleotide-binding domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) is the best characterized inflammasome and there is emerging evidence of its role in a variety of inflammatory pain conditions, including migraine. In this review, we discuss, from an inflammasome point of view, cortical spreading depolarization (CSD)-induced neuroinflammatory signaling in brain parenchyma, the connection with genetic factors that make the brain vulnerable to CSD, and the relation of the inflammasome with diseases that are co-morbid with migraine, including stroke, epilepsy, and the possible links with COVID-19 infection.

CONCLUSION:

Neuroinflammatory pathways, specifically those involving inflammasome proteins, seem promising candidates as treatment targets, and perhaps even biomarkers, in migraine.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 / Transtornos de Enxaqueca Limite: Humans Idioma: En Revista: J Headache Pain Assunto da revista: MEDICINA INTERNA / NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Turquia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 / Transtornos de Enxaqueca Limite: Humans Idioma: En Revista: J Headache Pain Assunto da revista: MEDICINA INTERNA / NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Turquia