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Low miR-214-5p Expression Correlates With Aggressive Subtypes of Pediatric ALCL With Non-Common Histology.
Di Battista, Piero; Lovisa, Federica; Gaffo, Enrico; Gallingani, Ilaria; Damanti, Carlotta C; Garbin, Anna; Ferrone, Lavinia; Carraro, Elisa; Pillon, Marta; Lo Nigro, Luca; Mura, Rossella; Pizzi, Marco; Guzzardo, Vincenza; Dei Tos, Angelo Paolo; Biffi, Alessandra; Bortoluzzi, Stefania; Mussolin, Lara.
Afiliação
  • Di Battista P; Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy.
  • Lovisa F; Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy.
  • Gaffo E; Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy.
  • Gallingani I; Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy.
  • Damanti CC; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Garbin A; Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy.
  • Ferrone L; Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy.
  • Carraro E; Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy.
  • Pillon M; Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy.
  • Lo Nigro L; Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy.
  • Mura R; Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy.
  • Pizzi M; Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy.
  • Guzzardo V; Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy.
  • Dei Tos AP; Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy.
  • Biffi A; Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy.
  • Bortoluzzi S; Center of Pediatric Hematology Oncology, Azienda Policlinico G. Rodolico - San Marco, Catania, Italy.
  • Mussolin L; Department of Paediatric Haematology-Oncology, Ospedale Pediatrico Microcitemico, Cagliari, Italy.
Front Oncol ; 11: 663221, 2021.
Article em En | MEDLINE | ID: mdl-34113568
ABSTRACT
The unsatisfactory cure rate of relapsing ALK-positive Anaplastic Large-Cell Lymphoma (ALCL) of childhood calls for the identification of new prognostic markers. Here, the small RNA landscape of pediatric ALK-positive ALCL was defined by RNA sequencing. Overall, 121 miRNAs were significantly dysregulated in ALCL compared to non-neoplastic lymph nodes. The most up-regulated miRNA was miR-21-5p, whereas miR-19a-3p and miR-214-5p were reduced in ALCL. Characterization of miRNA expression in cases that relapsed after first line therapy disclosed a significant association between miR-214-5p down-regulation and aggressive non-common histology. Our results suggest that miR-214-5p level may help to refine the prognostic stratification of pediatric ALK-positive ALCL.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Oncol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Oncol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália