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"One-Two Punch": Synergistic ß-Lactam Combinations for Mycobacterium abscessus and Target Redundancy in the Inhibition of Peptidoglycan Synthesis Enzymes.
Nguyen, David C; Dousa, Khalid M; Kurz, Sebastian G; Brown, Sheldon T; Drusano, George; Holland, Steven M; Kreiswirth, Barry N; Boom, W Henry; Daley, Charles L; Bonomo, Robert A.
Afiliação
  • Nguyen DC; Division of Infectious Diseases and HIV Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
  • Dousa KM; Division of Pediatric Infectious Diseases, Rainbow Babies and Children's Hospital, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
  • Kurz SG; Department of Internal Medicine and Infectious Diseases, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • Brown ST; Mount Sinai National Jewish Respiratory Institute, New York, New York, USA.
  • Drusano G; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Holland SM; Department of Medicine, James J. Peters VA Medical Center, Bronx, New York, USA.
  • Kreiswirth BN; Institute for Therapeutic Innovation, University of Florida, Orlando, Florida, USA.
  • Boom WH; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Daley CL; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
  • Bonomo RA; Division of Infectious Diseases and HIV Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Clin Infect Dis ; 73(8): 1532-1536, 2021 10 20.
Article em En | MEDLINE | ID: mdl-34113990
Mycobacterium abscessus subsp. abscessus is one of the most difficult pathogens to treat and its incidence in disease is increasing. Dual ß-lactam combinations act synergistically in vitro but are not widely employed in practice. A recent study shows that a combination of imipenem and ceftaroline significantly lowers the minimum inhibitory concentration of clinical isolates, despite both drugs targeting the same peptidoglycan synthesis enzymes. The underlying mechanism of this effect provides a basis for further investigations of dual ß-lactam combinations in the treatment of M. abscessus subsp. abscessus, eventually leading to a clinical trial. Furthermore, dual ß-lactam strategies may be explored for other difficult mycobacterial infections.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mycobacterium abscessus / Infecções por Mycobacterium não Tuberculosas Limite: Humans Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mycobacterium abscessus / Infecções por Mycobacterium não Tuberculosas Limite: Humans Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos