Thiazolidinediones (TZDs) enhance insulin secretory response via GPR40 and adenylate cyclase (AC).

Hwang, Mina; Kim, Hyo-Sup; Jin, Sang-Man; Hur, Kyu Yeon; Kim, Jae-Hyeon; Lee, Moon-Kyu

Hwang, Mina; Kim, Hyo-Sup; Jin, Sang-Man; Hur, Kyu Yeon; Kim, Jae-Hyeon; Lee, Moon-Kyu.

Afiliação

Hwang M; Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Kim HS; Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Jin SM; Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Hur KY; Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Kim JH; Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Lee MK; Division of Endocrinology and Metabolism, Department of Internal Medicine, Eulji University Hospital, Uijeongbu Medical Center, Eulji University, Uijeongbu, Korea.

J Cell Physiol ; 236(12): 8137-8147, 2021 12.

Article em En | MEDLINE | ID: mdl-34133753

ABSTRACT

ABSTRACT

Thiazolidinediones are synthetic PPARÎ³ ligands that enhance insulin sensitivity, and that could increase insulin secretion from ß-cells. However, the functional role and mechanism(s) of action in pancreatic ß-cells have not been investigated in detail.

Assuntos

Adenilil Ciclases/efeitos dos fármacos; Secreção de Insulina/efeitos dos fármacos; Células Secretoras de Insulina/efeitos dos fármacos; Tiazolidinedionas/farmacologia; Animais; Humanos; Hipoglicemiantes/metabolismo; Hipoglicemiantes/farmacologia; Insulina/metabolismo; Células Secretoras de Insulina/metabolismo; Ligantes; Receptores Acoplados a Proteínas G/efeitos dos fármacos

Palavras-chave

GPR40; adenylyl cyclase; cAMP; glucolipotoxicity; insulin secretion; lobeglitazone

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenilil Ciclases / Tiazolidinedionas / Células Secretoras de Insulina / Secreção de Insulina Limite: Animals / Humans Idioma: En Revista: J Cell Physiol Ano de publicação: 2021 Tipo de documento: Article

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