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Alternatones A and B, two polyketides possessing novel skeletons from entophyte Alternaria alternate L-10.
Zhang, Xuan; Liu, Xian-Xian; Xing, Yin-Nan; Zhang, Mei; Zhao, Yang; Wei, Yuan-Yuan; Zhang, Bo; Jiao, Rui-Hua.
Afiliação
  • Zhang X; State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing 210023, China.
  • Liu XX; State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing 210023, China.
  • Xing YN; State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing 210023, China.
  • Zhang M; State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing 210023, China.
  • Zhao Y; State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing 210023, China.
  • Wei YY; State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing 210023, China.
  • Zhang B; State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing 210023, China.
  • Jiao RH; State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing 210023, China.
J Asian Nat Prod Res ; 24(4): 353-360, 2022 Apr.
Article em En | MEDLINE | ID: mdl-34142621
ABSTRACT
On our ongoing searching for bioactive natural products derived from entophytes, two polyketides possessing novel skeletons, alternatones A-B (1-2), were identified from the culture of Alternaria alternate L-10. Their structures were established by a combination of spectroscopic and single-crystal X-ray diffraction with Cu Ka radiation. Alternatone A (1) exhibited cytotoxic activity against human hepatoma carcinoma HepG-2 cell line. The putative biosynthetic pathways for compounds 1-2 were also proposed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Policetídeos / Antineoplásicos Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Policetídeos / Antineoplásicos Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China