A phase II study of human allogeneic liver-derived progenitor cell therapy for acute-on-chronic liver failure and acute decompensation.

Nevens, Frederik; Gustot, Thierry; Laterre, Pierre-François; Lasser, Luc L; Haralampiev, Lyudmil E; Vargas, Victor; Lyubomirova, Desislava; Albillos, Agustin; Najimi, Mustapha; Michel, Sébastien; Stoykov, Ivaylo; Gordillo, Noelia; Vainilovich, Yelena; Barthel, Virginie; Clerget-Chossat, Nathalie; Sokal, Etienne M

Nevens, Frederik; Gustot, Thierry; Laterre, Pierre-François; Lasser, Luc L; Haralampiev, Lyudmil E; Vargas, Victor; Lyubomirova, Desislava; Albillos, Agustin; Najimi, Mustapha; Michel, Sébastien; Stoykov, Ivaylo; Gordillo, Noelia; Vainilovich, Yelena; Barthel, Virginie; Clerget-Chossat, Nathalie; Sokal, Etienne M.

Afiliação

Nevens F; Department of Gastroenterology and Hepatology, University Hospitals, KU Leuven, Belgium.
Gustot T; Department of Gastroenterology and Hepato-Pancreatology, C.U.B. Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Laterre PF; Intensive Care Unit, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium.
Lasser LL; Gastroenterology Clinic, CHU Brugmann, Brussels, Belgium.
Haralampiev LE; Department of Hepatogastroenterology, CHU Brugmann, Brussels, Belgium.
Vargas V; Department of Internal Diseases, Multiprofile Hospital for Active Treatment (MEDICA), Ruse, Bulgaria.
Lyubomirova D; Liver Unit, Hospital Vall d'Hebron, Universitat Autònoma Barcelona, CIBERehd, Barcelona, Spain.
Albillos A; Department of Clinical Gastroenterology with Hepatology, Gastroenterology Clinic, University Multiprofile Hospital for Active Treatment "Georgi Stranski", Pleven, Bulgaria.
Najimi M; Gastroenterology and Hepatology, University Hospital Ramón y Cajal, Madrid, Spain.
Michel S; UCLouvain, Institute of Experimental and Clinical Research (IREC), Laboratory of Pediatric Hepatology and Cell Therapy (PEDI), Brussels, Belgium.
Stoykov I; Promethera Biosciences, Mont-Saint-Guibert, Belgium.
Gordillo N; Promethera Biosciences, Mont-Saint-Guibert, Belgium.
Vainilovich Y; Promethera Biosciences, Mont-Saint-Guibert, Belgium.
Barthel V; Promethera Biosciences, Mont-Saint-Guibert, Belgium.
Clerget-Chossat N; Promethera Biosciences, Mont-Saint-Guibert, Belgium.
Sokal EM; Promethera Biosciences, Mont-Saint-Guibert, Belgium.

JHEP Rep ; 3(4): 100291, 2021 Aug.

Article em En | MEDLINE | ID: mdl-34169246

Palavras-chave

ACLF, acute-on-chronic liver failure; AD, acute decompensation of liver cirrhosis; AE, adverse event; AESI, AE of special interest; ATMP, advanced therapy medicinal product; Alcoholic liver disease; BW, body weight; CRP, C-reactive protein; EASL-CLIF, European Association for the Study of Chronic Liver Failure; HALPC, human allogeneic liver-derived progenitor cells; INR, international normalised ratio; Liver regenerative medicine; MELD, model for end-stage liver disease; MSC, mesenchymal stem cells; SAE, serious AE; SAS, safety analysis set; SUSAR, suspected unexpected serious adverse reaction; Stem cell; TEG, thromboelastography; TGT, thrombin generation test; i.v., intravenous

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JHEP Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Bélgica

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