Construction of Axially Chiral Arylborons via Atroposelective Miyaura Borylation.

Yang, Kai; Mao, Yanfei; Xu, Jie; Wang, Hao; He, Yong; Li, Wangyang; Song, Qiuling

Yang, Kai; Mao, Yanfei; Xu, Jie; Wang, Hao; He, Yong; Li, Wangyang; Song, Qiuling.

Afiliação

Yang K; Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China.
Mao Y; Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China.
Xu J; Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China.
Wang H; Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China.
He Y; Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China.
Li W; Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China.
Song Q; Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China.

J Am Chem Soc ; 143(27): 10048-10053, 2021 07 14.

Article em En | MEDLINE | ID: mdl-34180660

ABSTRACT

ABSTRACT

Compared with the well-developed centrally chiral boron chemistry, C-B axially chiral chemistry remains elusive and challenging. Herein we report the first atroposelective Miyaura borylation of bromoarenes with unsymmetrical diboron reagents for the direct catalytic synthesis of optically active atropisomeric arylborons. This reaction features broad substrate scope and produces axially chiral arylborons with high yields and good enantioselectivities.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Am Chem Soc Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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