Human neural organoids: Models for developmental neurobiology and disease.
Dev Biol
; 478: 102-121, 2021 10.
Article
em En
| MEDLINE
| ID: mdl-34181916
ABSTRACT
Human organoids stand at the forefront of basic and translational research, providing experimentally tractable systems to study human development and disease. These stem cell-derived, in vitro cultures can generate a multitude of tissue and organ types, including distinct brain regions and sensory systems. Neural organoid systems have provided fundamental insights into molecular mechanisms governing cell fate specification and neural circuit assembly and serve as promising tools for drug discovery and understanding disease pathogenesis. In this review, we discuss several human neural organoid systems, how they are generated, advances in 3D imaging and bioengineering, and the impact of organoid studies on our understanding of the human nervous system.
Palavras-chave
Brain; CRISPR; Cerebellar organoid; Cerebellum; Cerebral cortex; Cortical organoid; Embryoid bodies; Embryonic stem cells; Hippocampal organoid; Hippocampus; Human; Hypothalamic organoid; Hypothalamus; Induced-pluripotent stem cells; Organoid; Retina; Retinal organoid; Thalamic organoid; Thalamus; scRNA-seq
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Encéfalo
/
Encefalopatias
/
Organoides
Limite:
Humans
Idioma:
En
Revista:
Dev Biol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos