Formulation and evaluation of a α-linolenic acid and vitamin E succinate microemulsion with low surfactant content and free of co-surfactant for use as a nutritional supplement.
Food Chem
; 364: 130433, 2021 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-34186478
ABSTRACT
Herein, we have designed an alcohol-free and low-surfactant microemulsion to safely and effectively supply α-linolenic acid (ALA) and vitamin E (VE). Ternary phase diagrams show that the use of medium- or short-chain alcohols as the co-surfactant (CoS) was unfavorable for the formation of the ALA microemulsion due to the competitive hydrogen bonding effect and vitamin E succinate (VES) significantly increased the ALA microemulsion region by improving the hydrophilicity of the oil phase. The optimal microemulsion formulation (Mav) was 6.86% ALA, 1.14% VES, 12% surfactant and 80% water, with uniformly dispersed spherical particles with diameters of ~ 25.41 nm and viscosity of 35.17 mPa·s. The Mav was stable to high temperature, ionic strength and pH, and exhibited good physical and anti-oxidation stability. The Mav facilitated the release and hydrolysis of VES, indicating that the CoS-free microemulsion with low surfactant content is promising for the safe and effective supply of ALA and VE.
Palavras-chave
Co-surfactant free microemulsion; Release ability; Stability; Stearyl glycyrrhetinate (PubChem CID: 10700068).; Vitamin E acetate (PubChem CID: 86472); Vitamin E succinate; Vitamin E succinate (PubChem CID: 20353); d-α-Tocopherol polyethylene glycol 1000 succinate (PubChem CID: 71406); α-Linolenic acid; α-Linolenic acid (PubChem CID: 5280934)
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tensoativos
/
Suplementos Nutricionais
/
Alfa-Tocoferol
Idioma:
En
Revista:
Food Chem
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China