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Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-, Cefiderocol-Resistant ST-512 Klebsiella pneumoniae-Producing KPC-31, a D179Y Variant of KPC-3.
Tiseo, Giusy; Falcone, Marco; Leonildi, Alessandro; Giordano, Cesira; Barnini, Simona; Arcari, Gabriele; Carattoli, Alessandra; Menichetti, Francesco.
Afiliação
  • Tiseo G; Infectious Diseases Clinic, Department of Clinical and Experimental Medicine, Azienda Universitaria Ospedaliera Pisana, University of Pisa, Pisa, Italy.
  • Falcone M; Infectious Diseases Clinic, Department of Clinical and Experimental Medicine, Azienda Universitaria Ospedaliera Pisana, University of Pisa, Pisa, Italy.
  • Leonildi A; Microbiology Unit, Azienda Universitaria Ospedaliera Pisana, Pisa, Italy.
  • Giordano C; Microbiology Unit, Azienda Universitaria Ospedaliera Pisana, Pisa, Italy.
  • Barnini S; Microbiology Unit, Azienda Universitaria Ospedaliera Pisana, Pisa, Italy.
  • Arcari G; Department of Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Carattoli A; Department of Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Menichetti F; Infectious Diseases Clinic, Department of Clinical and Experimental Medicine, Azienda Universitaria Ospedaliera Pisana, University of Pisa, Pisa, Italy.
Open Forum Infect Dis ; 8(6): ofab141, 2021 Jun.
Article em En | MEDLINE | ID: mdl-34189161
ABSTRACT
A 68-year-old man had recurrent bacteremia by Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae resistant to ceftazidime-avibactam and cefiderocol. The sequencing of a target region showed that it harbored a KPC-3 variant enzyme (D179Y; KPC-31), which confers resistance to ceftazidime-avibactam and restores meropenem susceptibility. The patient was successfully treated with meropenem-vaborbactam.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Open Forum Infect Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Open Forum Infect Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália