Hydrocephalus Revisited: New Insights into Dynamics of Neurofluids on Macro- and Microscales.
Neuropediatrics
; 52(4): 233-241, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-34192788
ABSTRACT
New experimental and clinical findings question the historic view of hydrocephalus and its 100-year-old classification. In particular, real-time magnetic resonance imaging (MRI) evaluation of cerebrospinal fluid (CSF) flow and detailed insights into brain water regulation on the molecular scale indicate the existence of at least three main mechanisms that determine the dynamics of neurofluids (1) inspiration is a major driving force; (2) adequate filling of brain ventricles by balanced CSF upsurge is sensed by cilia; and (3) the perivascular glial network connects the ependymal surface to the pericapillary Virchow-Robin spaces. Hitherto, these aspects have not been considered a common physiologic framework, improving knowledge and therapy for severe disorders of normal-pressure and posthemorrhagic hydrocephalus, spontaneous intracranial hypotension, and spaceflight disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Hidrocefalia
Tipo de estudo:
Etiology_studies
Limite:
Aged80
/
Humans
Idioma:
En
Revista:
Neuropediatrics
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Alemanha