Activation of 8-17 DNAzyme with extra functional group at conserved residues is related to catalytic metal ion.
Bioorg Med Chem Lett
; 48: 128234, 2021 09 15.
Article
em En
| MEDLINE
| ID: mdl-34214510
ABSTRACT
In 8-17 DNAzyme, the end loop A6G7C8 is a highly conserved motif. Here we reported an activation approach by specific chemical modifications on A6 and C8 for more efficient Ca2+-mediated reaction. The importance of the end loop was further highlighted and its critical conservation broken for more powerful catalysts.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cálcio
/
DNA Catalítico
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China