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Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.
Soriano, Ignacio; Vazquez, Enrique; De Leon, Nagore; Bertrand, Sibyl; Heitzer, Ellen; Toumazou, Sophia; Bo, Zhihan; Palles, Claire; Pai, Chen-Chun; Humphrey, Timothy C; Tomlinson, Ian; Cotterill, Sue; Kearsey, Stephen E.
Afiliação
  • Soriano I; ZRAB, University of Oxford, Oxford, United Kingdom.
  • Vazquez E; Edinburgh Cancer Research Centre, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
  • De Leon N; Genomics Unit, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
  • Bertrand S; ZRAB, University of Oxford, Oxford, United Kingdom.
  • Heitzer E; Edinburgh Cancer Research Centre, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
  • Toumazou S; ZRAB, University of Oxford, Oxford, United Kingdom.
  • Bo Z; Institute of Human Genetics, Diagnostic & Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.
  • Palles C; ZRAB, University of Oxford, Oxford, United Kingdom.
  • Pai CC; MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
  • Humphrey TC; ZRAB, University of Oxford, Oxford, United Kingdom.
  • Tomlinson I; Gastrointestinal Cancer Genetics Laboratory, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
  • Cotterill S; MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
  • Kearsey SE; MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
PLoS Genet ; 17(7): e1009526, 2021 07.
Article em En | MEDLINE | ID: mdl-34228709
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Schizosaccharomyces / Proteínas de Schizosaccharomyces pombe / DNA Polimerase II / Replicação do DNA / Mutação Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: PLoS Genet Assunto da revista: GENETICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Schizosaccharomyces / Proteínas de Schizosaccharomyces pombe / DNA Polimerase II / Replicação do DNA / Mutação Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: PLoS Genet Assunto da revista: GENETICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido