Long-term weight changes and risk of rheumatoid arthritis among women in a prospective cohort: a marginal structural model approach.
Rheumatology (Oxford)
; 61(4): 1430-1439, 2022 04 11.
Article
em En
| MEDLINE
| ID: mdl-34247242
ABSTRACT
OBJECTIVE:
To examine the association of long-term weight change with RA risk in a large prospective cohort study.METHODS:
The Nurses' Health Study II started in 1989 (baseline); after exclusions, we studied 108 505 women 25-42 years old without RA. Incident RA was reported by participants and confirmed by medical record review. Body weight was reported biennially through 2015. We investigated two time-varying exposures weight changes from baseline and from age 18; change was divided into five categories. We used a marginal structural model approach to account for time-varying weight change and covariates.RESULTS:
Over 2 583 266 person-years, with a median follow-up time of 25.3 years, 541 women developed RA. Compared with women with stable weight from baseline, weight change was significantly associated with increased RA risk [weight gain 2-<10 kg RR = 1.98 (95% CI 1.38, 2.85); 10-<20 kg RR = 3.28 (95% CI 2.20, 4.89); ≥20 kg RR = 3.81 (95% CI 2.39, 6.07); and weight loss >2 kg RR = 2.05 (95% CI 1.28, 3.28)]. Weight gain of 10 kg or more from age 18 compared with stable weight was also associated with increased RA risk [10-< 20 kg RR = 2.12 (95% CI 1.37, 3.27), ≥20 kg RR = 2.31 (95% CI 1.50, 3.56)]. Consistent findings were observed for seropositive and seronegative RA.CONCLUSION:
Long-term weight gain was strongly associated with increased RA risk in women, with weight gain of ≥20 kg associated with more than a three-fold increased RA risk. Maintenance of healthy weight may be a strategy to prevent or delay RA.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
Tipo de estudo:
Etiology_studies
/
Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
Idioma:
En
Revista:
Rheumatology (Oxford)
Assunto da revista:
REUMATOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article