Your browser doesn't support javascript.
loading
Factors influencing SARS-CoV-2 transmission and outbreak control measures in densely populated settings.
Pung, Rachael; Lin, Bernard; Maurer-Stroh, Sebastian; Sirota, Fernanda L; Mak, Tze Minn; Octavia, Sophie; Pang, Junxiong; Tan, Iain Beehuat; Tan, Clive; Ong, Biauw Chi; Cook, Alex R; Lee, Vernon J.
Afiliação
  • Pung R; Ministry of Health, Singapore, Singapore. Rachael_PUNG@moh.gov.sg.
  • Lin B; Ministry of Manpower, Singapore, Singapore.
  • Maurer-Stroh S; Government Technology Agency, Singapore, Singapore.
  • Sirota FL; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore.
  • Mak TM; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
  • Octavia S; National Public Health Laboratory, National Centre for Infectious Diseases, Singapore, Singapore.
  • Pang J; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore.
  • Tan IB; National Public Health Laboratory, National Centre for Infectious Diseases, Singapore, Singapore.
  • Tan C; National Public Health Laboratory, National Centre for Infectious Diseases, Singapore, Singapore.
  • Ong BC; Ministry of Health, Singapore, Singapore.
  • Cook AR; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
  • Lee VJ; Department of Medical Oncology, National Cancer Centre, Singhealth, Singapore, Singapore.
Sci Rep ; 11(1): 15297, 2021 07 27.
Article em En | MEDLINE | ID: mdl-34315928
Starting with a handful of SARS-CoV-2 infections in dormitory residents in late March 2020, rapid transmission in their dense living environments ensued and by October 2020, more than 50,000 acute infections were identified across various dormitories in Singapore. The aim of the study is to identify combination of factors facilitating SARS-CoV-2 transmission and the impact of control measures in a dormitory through extensive epidemiological, serological and phylogenetic investigations, supported by simulation models. Our findings showed that asymptomatic cases and symptomatic cases who did not seek medical attention were major drivers of the outbreak. Furthermore, each resident had about 30 close contacts and each infected resident spread to 4.4 (IQR 3.5-5.3) others at the start of the outbreak. The final attack rate of the current outbreak was 76.2% (IQR 70.6-98.0%) and could be reduced by further 10% under a modified dormitory housing condition. These findings are important when designing living environments in a post COVID-19 future to reduce disease spread and facilitate rapid implementation of outbreak control measures.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Surtos de Doenças / Densidade Demográfica / SARS-CoV-2 / COVID-19 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Singapura

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Surtos de Doenças / Densidade Demográfica / SARS-CoV-2 / COVID-19 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Singapura