SIMPLE Is an Endosomal Regulator That Protects Against NAFLD by Targeting the Lysosomal Degradation of EGFR.

Song, Jingjing; Liu, Yupeng; Wan, Juan; Zhao, Guang-Nian; Wang, Jian-Cheng; Dai, Zhifei; Hu, Sha; Yang, Ling; Liu, Zhen; Fu, Yi; Dong, Erdan; Tang, Yi-Da

Song, Jingjing; Liu, Yupeng; Wan, Juan; Zhao, Guang-Nian; Wang, Jian-Cheng; Dai, Zhifei; Hu, Sha; Yang, Ling; Liu, Zhen; Fu, Yi; Dong, Erdan; Tang, Yi-Da.

Afiliação

Song J; Department of Cardiology, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Liu Y; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wan J; Department of Cardiology, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhao GN; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wang JC; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Dai Z; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Hu S; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Yang L; Department of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China.
Liu Z; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Fu Y; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Dong E; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Tang YD; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.

Hepatology ; 74(6): 3091-3109, 2021 12.

Article em En | MEDLINE | ID: mdl-34320238

Assuntos

Proteínas de Ligação a DNA/metabolismo; Receptores ErbB/metabolismo; Hepatopatia Gordurosa não Alcoólica/patologia; Proteínas Nucleares/metabolismo; Fatores de Transcrição/metabolismo; Animais; Biópsia; Células Cultivadas; Proteínas de Ligação a DNA/antagonistas & inibidores; Proteínas de Ligação a DNA/genética; Dieta Hiperlipídica/efeitos adversos; Receptores ErbB/antagonistas & inibidores; Feminino; Técnicas de Silenciamento de Genes; Hepatócitos; Humanos; Metabolismo dos Lipídeos/efeitos dos fármacos; Metabolismo dos Lipídeos/genética; Fígado/metabolismo; Fígado/patologia; Lisossomos/metabolismo; Masculino; Camundongos; Camundongos Knockout; Hepatopatia Gordurosa não Alcoólica/etiologia; Hepatopatia Gordurosa não Alcoólica/metabolismo; Proteínas Nucleares/genética; Cultura Primária de Células; Proteólise; Fatores de Transcrição/antagonistas & inibidores; Fatores de Transcrição/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas Nucleares / Proteínas de Ligação a DNA / Hepatopatia Gordurosa não Alcoólica / Receptores ErbB Tipo de estudo: Etiology_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Hepatology Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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