Analyzing the impact of CFP1 mutational landscape on epigenetic signaling.

Yang, Yidai; Yang, Yaqing; Chan, Kin; Couture, Jean-Francois

Yang, Yidai; Yang, Yaqing; Chan, Kin; Couture, Jean-Francois.

Afiliação

Yang Y; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.
Yang Y; Shanghai Institute of Materia Medica-University of Ottawa Research Center in Systems and Personalized Pharmacology, University of Ottawa, Ottawa, ON, Canada.
Chan K; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Couture JF; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.

FASEB J ; 35(8): e21790, 2021 08.

Article em En | MEDLINE | ID: mdl-34320252

ABSTRACT

ABSTRACT

CXXC Zinc finger protein 1 (CFP1) is a multitasking protein playing essential roles during various developmental processes. Its ability to interact with several proteins contribute to several epigenetic events. Here, we review CFP1's functions and its impact on DNA methylation and the post-translational modification of histone proteins such as lysine acetylation and methylation. We will also discuss the potential role of CFP1 in carcinogenesis and the impact of the mutations identified in patients suffering from various cancers.

Assuntos

Epigênese Genética; Mutação; Neoplasias/metabolismo; Transativadores/metabolismo; Animais; Regulação Neoplásica da Expressão Gênica; Humanos; Transativadores/genética

Palavras-chave

CFP1; cancer; epigenetics

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transativadores / Epigênese Genética / Mutação / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google