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Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2.
Yang, Jing; Weisberg, Ellen L; Liu, Xiaoxi; Magin, Robert S; Chan, Wai Cheung; Hu, Bin; Schauer, Nathan J; Zhang, Shengzhe; Lamberto, Ilaria; Doherty, Laura; Meng, Chengcheng; Sattler, Martin; Cabal-Hierro, Lucia; Winer, Eric; Stone, Richard; Marto, Jarrod A; Griffin, James D; Buhrlage, Sara J.
Afiliação
  • Yang J; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Weisberg EL; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Liu X; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Magin RS; Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Chan WC; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Hu B; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Schauer NJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Zhang S; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Lamberto I; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Doherty L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Meng C; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Sattler M; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Cabal-Hierro L; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Winer E; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Stone R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Marto JA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Griffin JD; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Buhrlage SJ; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Leukemia ; 36(1): 210-220, 2022 01.
Article em En | MEDLINE | ID: mdl-34326465
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Janus Quinase 2 / Bibliotecas de Moléculas Pequenas / Enzimas Desubiquitinantes / Mutação / Transtornos Mieloproliferativos Tipo de estudo: Prognostic_studies Limite: Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Leukemia Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Janus Quinase 2 / Bibliotecas de Moléculas Pequenas / Enzimas Desubiquitinantes / Mutação / Transtornos Mieloproliferativos Tipo de estudo: Prognostic_studies Limite: Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Leukemia Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos