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RORγt agonist synergizes with CTLA-4 antibody to inhibit tumor growth through inhibition of Treg cells via TGF-ß signaling in cancer.
Tian, En-Ming; Yu, Ming-Cheng; Feng, Mei; Lu, Li-Xue; Liu, Cheng-Long; Shen, Li-An; Wang, Yong-Hui; Xie, Qiong; Zhu, Di.
Afiliação
  • Tian EM; Department of Pharmacology, School of Basic Medical Sciences, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Yu MC; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Feng M; Department of Pharmacology, School of Basic Medical Sciences, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Lu LX; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Liu CL; Department of Pharmacology, School of Basic Medical Sciences, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Shen LA; Department of Pharmacology, School of Basic Medical Sciences, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Wang YH; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Xie Q; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address: qxie@fudan.edu.cn.
  • Zhu D; Department of Pharmacology, School of Basic Medical Sciences, School of Pharmacy, Fudan University, Shanghai 201203, China; School of Basic Medical Sciences, Fudan Unvieristy, Shanghai 200032, China. Electronic address: zhudi@fudan.edu.cn.
Pharmacol Res ; 172: 105793, 2021 10.
Article em En | MEDLINE | ID: mdl-34339836
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares / Antígeno CTLA-4 / Anticorpos / Neoplasias / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares / Antígeno CTLA-4 / Anticorpos / Neoplasias / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China