Telmisartan ameliorates cardiac fibrosis and diastolic function in cardiorenal heart failure with preserved ejection fraction.

Chang, Di; Xu, Ting-Ting; Zhang, Shi-Jun; Cai, Yu; Min, Shu-Dan; Zhao, Zhen; Lu, Chun-Qiang; Wang, Yuan-Cheng; Ju, Shenghong

Chang, Di; Xu, Ting-Ting; Zhang, Shi-Jun; Cai, Yu; Min, Shu-Dan; Zhao, Zhen; Lu, Chun-Qiang; Wang, Yuan-Cheng; Ju, Shenghong.

Afiliação

Chang D; Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
Xu TT; Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
Zhang SJ; Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
Cai Y; Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
Min SD; Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
Zhao Z; Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
Lu CQ; Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
Wang YC; Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
Ju S; Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.

Exp Biol Med (Maywood) ; 246(23): 2511-2521, 2021 12.

Article em En | MEDLINE | ID: mdl-34342551

Assuntos

Bloqueadores do Receptor Tipo 1 de Angiotensina II/farmacologia; Síndrome Cardiorrenal/tratamento farmacológico; Fibrose/tratamento farmacológico; Insuficiência Cardíaca/tratamento farmacológico; Telmisartan/farmacologia; Animais; Anti-Hipertensivos/farmacologia; Velocidade do Fluxo Sanguíneo/efeitos dos fármacos; Pressão Sanguínea/efeitos dos fármacos; Síndrome Cardiorrenal/patologia; Diástole/efeitos dos fármacos; Modelos Animais de Doenças; Ecocardiografia; Fibrose/patologia; Insuficiência Cardíaca/patologia; Hipertrofia Ventricular Esquerda/tratamento farmacológico; Masculino; Peptídeo Natriurético Encefálico/análise; Ratos; Ratos Sprague-Dawley; Insuficiência Renal Crônica/tratamento farmacológico; Insuficiência Renal Crônica/patologia; Volume Sistólico/efeitos dos fármacos; Função Ventricular Esquerda/efeitos dos fármacos; Remodelação Ventricular/efeitos dos fármacos

Palavras-chave

Heart failure with preserved ejection fraction; cardiac fibrosis; cardiorenal syndrome; chronic kidney disease; diastolic function; renin-angiotensin-aldosterone system

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose / Bloqueadores do Receptor Tipo 1 de Angiotensina II / Síndrome Cardiorrenal / Telmisartan / Insuficiência Cardíaca Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Exp Biol Med (Maywood) Assunto da revista: BIOLOGIA / FISIOLOGIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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