[Bioavailability of heptaminol in healthy subjects]. / Untersuchungen zur Bioverfügbarkeit von Heptaminol bei Probanden.
Arzneimittelforschung
; 37(10): 1182-5, 1987 Oct.
Article
em De
| MEDLINE
| ID: mdl-3435592
ABSTRACT
In ten healthy volunteers the plasma and urine concentrations of heptaminol (Heptylon) were determined by high-performance liquid chromatography after intravenous administration of 250 mg heptaminol and oral intake of 2 x 150 mg heptaminol in tablet form, and the pharmacokinetic parameters were calculated. Heptaminol was rapidly and entirely absorbed following oral administration of heptaminol. Mean plasma peak concentrations of 1.6 mg/l were reached after 1.8 h, the area under the plasma concentration-time curve was equal to that after intravenous administration. The dominant terminal plasma half-life was 2.5-2.7 h. The total clearance amounted to 700 ml/min, and nearly all the dose given was recovered unchanged in urine within 24 h, indicating renal elimination by glomerular filtration and tubular secretion without metabolization.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Amino Álcoois
/
Heptaminol
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
De
Revista:
Arzneimittelforschung
Ano de publicação:
1987
Tipo de documento:
Article