Colloidally Stabilized DSPE-PEG-Glucose/Calcium Phosphate Hybrid Nanocomposites for Enhanced Photodynamic Cancer Therapy via Complementary Mitochondrial Ca<sup>2+</sup> Overload and Autophagy Inhibition.

Wang, Xuan; Li, Yunhao; Deng, Xiongwei; Jia, Fan; Cui, Xinyue; Lu, Jianqing; Pan, Zian; Wu, Yan

Colloidally Stabilized DSPE-PEG-Glucose/Calcium Phosphate Hybrid Nanocomposites for Enhanced Photodynamic Cancer Therapy via Complementary Mitochondrial Ca²⁺ Overload and Autophagy Inhibition.

Wang, Xuan; Li, Yunhao; Deng, Xiongwei; Jia, Fan; Cui, Xinyue; Lu, Jianqing; Pan, Zian; Wu, Yan.

Afiliação

Wang X; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, No. 11 First North Road, Zhongguancun, Beijing 100190, P. R. China.
Li Y; University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
Deng X; Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, P. R. China.
Jia F; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, No. 11 First North Road, Zhongguancun, Beijing 100190, P. R. China.
Cui X; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, No. 11 First North Road, Zhongguancun, Beijing 100190, P. R. China.
Lu J; University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
Pan Z; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, No. 11 First North Road, Zhongguancun, Beijing 100190, P. R. China.
Wu Y; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, No. 11 First North Road, Zhongguancun, Beijing 100190, P. R. China.

ACS Appl Mater Interfaces ; 13(33): 39112-39125, 2021 Aug 25.

Article em En | MEDLINE | ID: mdl-34384220

Assuntos

Autofagia/efeitos dos fármacos; Fosfatos de Cálcio/química; Glucose/química; Indóis/química; Nanocompostos/química; Fosfatidiletanolaminas/química; Fármacos Fotossensibilizantes/química; Polietilenoglicóis/química; Animais; Transporte Biológico; Melhoramento Biomédico; Feminino; Humanos; Indóis/metabolismo; Indóis/farmacologia; Camundongos Endogâmicos BALB C; Mitocôndrias/metabolismo; Mitocôndrias/ultraestrutura; Neoplasias/diagnóstico por imagem; Neoplasias/terapia; Fosfolipídeos/química; Fotoquimioterapia; Fármacos Fotossensibilizantes/farmacologia; Pirróis/química; Pirróis/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Transdução de Sinais; Propriedades de Superfície; Distribuição Tecidual

Palavras-chave

DSPE-PEG-glucose; ROS; autophagy inhibition; calcium phosphate; mitochondrial Ca2+ overload; photodynamic therapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidiletanolaminas / Polietilenoglicóis / Autofagia / Fosfatos de Cálcio / Fármacos Fotossensibilizantes / Nanocompostos / Glucose / Indóis Limite: Animals / Female / Humans Idioma: En Revista: ACS Appl Mater Interfaces Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2021 Tipo de documento: Article

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