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A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.
Baddock, Hannah T; Newman, Joseph A; Yosaatmadja, Yuliana; Bielinski, Marcin; Schofield, Christopher J; Gileadi, Opher; McHugh, Peter J.
Afiliação
  • Baddock HT; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS, UK.
  • Newman JA; Centre for Medicines Discovery, University of Oxford, ORCRB, OX3 7DQ, UK.
  • Yosaatmadja Y; Centre for Medicines Discovery, University of Oxford, ORCRB, OX3 7DQ, UK.
  • Bielinski M; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
  • Schofield CJ; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
  • Gileadi O; Centre for Medicines Discovery, University of Oxford, ORCRB, OX3 7DQ, UK.
  • McHugh PJ; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS, UK.
Nucleic Acids Res ; 49(16): 9294-9309, 2021 09 20.
Article em En | MEDLINE | ID: mdl-34387694
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Endonucleases / Exodesoxirribonucleases / Exonucleases Limite: Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Endonucleases / Exodesoxirribonucleases / Exonucleases Limite: Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido