Metformin Therapy in Autosomal Dominant Polycystic Kidney Disease: A Feasibility Study.

Brosnahan, Godela M; Wang, Wei; Gitomer, Berenice; Struemph, Taylor; George, Diana; You, Zhiying; Nowak, Kristen L; Klawitter, Jelena; Chonchol, Michel B

Brosnahan, Godela M; Wang, Wei; Gitomer, Berenice; Struemph, Taylor; George, Diana; You, Zhiying; Nowak, Kristen L; Klawitter, Jelena; Chonchol, Michel B.

Afiliação

Brosnahan GM; Division of Renal Diseases and Hypertension, Department of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, Colorado. Electronic address: godela.brosnahan@cuanschutz.edu.
Wang W; Division of Renal Diseases and Hypertension, Department of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, Colorado.
Gitomer B; Division of Renal Diseases and Hypertension, Department of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, Colorado.
Struemph T; Division of Renal Diseases and Hypertension, Department of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, Colorado.
George D; Division of Renal Diseases and Hypertension, Department of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, Colorado.
You Z; Division of Renal Diseases and Hypertension, Department of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, Colorado.
Nowak KL; Division of Renal Diseases and Hypertension, Department of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, Colorado.
Klawitter J; Division of Renal Diseases and Hypertension, Department of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, Colorado.
Chonchol MB; Division of Renal Diseases and Hypertension, Department of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, Colorado.

Am J Kidney Dis ; 79(4): 518-526, 2022 04.

Article em En | MEDLINE | ID: mdl-34391872

Assuntos

Metformina; Rim Policístico Autossômico Dominante; Adulto; Progressão da Doença; Estudos de Viabilidade; Taxa de Filtração Glomerular; Humanos; Rim; Metformina/uso terapêutico; Pessoa de Meia-Idade; Rim Policístico Autossômico Dominante/complicações; Rim Policístico Autossômico Dominante/tratamento farmacológico; Estudos Prospectivos

Palavras-chave

ADPKD progression; AMPK activator; autosomal dominant polycystic kidney disease (ADPKD); dose escalation; estimated glomerular filtration rate (eGFR); gastrointestinal symptoms; metformin; randomized controlled trial (RCT); renal function decline; safety; tolerability; total kidney volume (TKV)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rim Policístico Autossômico Dominante / Metformina Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Adult / Humans / Middle aged Idioma: En Revista: Am J Kidney Dis Ano de publicação: 2022 Tipo de documento: Article

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