Estimation of the lipophilicity of purine-2,6-dione-based TRPA1 antagonists and PDE4/7 inhibitors with analgesic activity.

Dabrowska, Monika; Starek, Malgorzata; Chlon-Rzepa, Grazyna; Zagórska, Agnieszka; Komsta, Lukasz; Jankowska, Agnieszka; Slusarczyk, Marietta; Pawlowski, Maciej

Dabrowska, Monika; Starek, Malgorzata; Chlon-Rzepa, Grazyna; Zagórska, Agnieszka; Komsta, Lukasz; Jankowska, Agnieszka; Slusarczyk, Marietta; Pawlowski, Maciej.

Afiliação

Dabrowska M; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, 9 Medyczna St, 30-688 Kraków, Poland.
Starek M; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, 9 Medyczna St, 30-688 Kraków, Poland. Electronic address: m.starek@uj.edu.pl.
Chlon-Rzepa G; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Medicinal Chemistry, 9 Medyczna St, 30-688 Kraków, Poland.
Zagórska A; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Medicinal Chemistry, 9 Medyczna St, 30-688 Kraków, Poland.
Komsta L; Medical University of Lublin, Faculty of Pharmacy, Department of Medicinal Chemistry, 4 Jaczewskiego St, 20-090 Lublin, Poland.
Jankowska A; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Medicinal Chemistry, 9 Medyczna St, 30-688 Kraków, Poland.
Slusarczyk M; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Medicinal Chemistry, 9 Medyczna St, 30-688 Kraków, Poland.
Pawlowski M; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Medicinal Chemistry, 9 Medyczna St, 30-688 Kraków, Poland.

Bioorg Med Chem Lett ; 49: 128318, 2021 10 01.

Article em En | MEDLINE | ID: mdl-34391892

Assuntos

Analgésicos/química; Benzenoacetamidas/química; Inibidores da Fosfodiesterase 4/química; Canal de Cátion TRPA1/antagonistas & inibidores; Xantinas/química; Nucleotídeo Cíclico Fosfodiesterase do Tipo 7/antagonistas & inibidores; Interações Hidrofóbicas e Hidrofílicas; Estrutura Molecular; Fenilbutiratos/química; Análise de Componente Principal; Relação Quantitativa Estrutura-Atividade

Palavras-chave

Chromatography; Lipophilicity; Multifunctional ligands; Principal Component Analysis; Purine-2,6-dione

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Xantinas / Benzenoacetamidas / Inibidores da Fosfodiesterase 4 / Canal de Cátion TRPA1 / Analgésicos Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Polônia

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