Transition-Metal-Free Alkylation and Acylation of Benzoxazinones with 1,4-Dihydropyridines.
J Org Chem
; 86(17): 12247-12256, 2021 09 03.
Article
em En
| MEDLINE
| ID: mdl-34406002
ABSTRACT
The direct functionalization of N-heterocycles is a vital transformation for the development of pharmaceuticals, functional materials, and other chemical entities. Herein, the transition-metal-free alkylation and acylation of C(sp2)-H bonds in biologically relevant 2-benzoxazinones with 1,4-dihydropyridines as readily accessible radical surrogates is described. Excellent functional group compatibility and a broad substrate scope were attained. Gram-scale reaction and transformations of the synthesized adducts via Suzuki coupling with heteroaryl boronic acids demonstrated the synthetic potential of the developed protocol.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Di-Hidropiridinas
/
Elementos de Transição
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2021
Tipo de documento:
Article