Estrogen receptor Alpha in human knee articular cartilage of healthy and osteoarthritic females.
J Orthop
; 27: 1-8, 2021.
Article
em En
| MEDLINE
| ID: mdl-34413582
ABSTRACT
OBJECTIVE:
Estrogen and osteoarthritis association has previously been proposed. This study evaluates the presence of estrogen receptors (ER)-α in articular cartilage, and its association.METHODS:
A prospective cohort study of women undergoing anterior cruciate ligament reconstruction (controls) or total knee arthroplasty (cases) was performed. Cartilage samples were processed and ER-α expression was quantified.RESULTS:
Twenty patients were included 12 cases and 8 controls. ER-α expression was higher in the case subjects.CONCLUSION:
Increased ER-α expression is associated with age, and degeneration. This suggests estrogen deficiency is a risk for osteoarthritis and is inversely related to proliferative looking chondrocytes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Orthop
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos