Structure-activity relationship, <i>in vitro</i> and <i>in vivo</i> evaluation of novel dienyl sulphonyl fluorides as selective BuChE inhibitors for the treatment of Alzheimer's disease.

Wu, Chengyao; Zhang, Guijuan; Zhang, Zai-Wei; Jiang, Xia; Zhang, Ziwen; Li, Huanhuan; Qin, Hua-Li; Tang, Wenjian

Structure-activity relationship, in vitro and in vivo evaluation of novel dienyl sulphonyl fluorides as selective BuChE inhibitors for the treatment of Alzheimer's disease.

Wu, Chengyao; Zhang, Guijuan; Zhang, Zai-Wei; Jiang, Xia; Zhang, Ziwen; Li, Huanhuan; Qin, Hua-Li; Tang, Wenjian.

Afiliação

Wu C; School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, China.
Zhang G; Management Center of Anhui Continuing Education Network Park, Anhui Open University, Hefei, China.
Zhang ZW; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, China.
Jiang X; School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, China.
Zhang Z; School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, China.
Li H; School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, China.
Qin HL; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, China.
Tang W; School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, China.

J Enzyme Inhib Med Chem ; 36(1): 1860-1873, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34425715

Assuntos

Doença de Alzheimer/tratamento farmacológico; Inibidores da Colinesterase/química; Colinesterases/metabolismo; Fármacos Neuroprotetores/química; Ácidos Sulfínicos/química; Alcinos/química; Amiloide/metabolismo; Animais; Comportamento Animal; Barreira Hematoencefálica/metabolismo; Sobrevivência Celular/efeitos dos fármacos; Inibidores da Colinesterase/farmacologia; Desenho de Fármacos; Humanos; Fígado; Masculino; Camundongos Endogâmicos ICR; Simulação de Acoplamento Molecular; Estrutura Molecular; Teste do Labirinto Aquático de Morris; Sistema Nervoso; Fármacos Neuroprotetores/farmacologia; Relação Estrutura-Atividade; Ácidos Sulfínicos/farmacologia

Palavras-chave

Acetylcholinesterase; Alzheimer's disease; anti-amyloid; butyrylcholinesterase; sulphonyl fluoride

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Sulfínicos / Inibidores da Colinesterase / Colinesterases / Fármacos Neuroprotetores / Doença de Alzheimer Limite: Animals / Humans / Male Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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