HOIP limits anti-tumor immunity by protecting against combined TNF and IFN-gamma-induced apoptosis.

Freeman, Andrew J; Vervoort, Stephin J; Michie, Jessica; Ramsbottom, Kelly M; Silke, John; Kearney, Conor J; Oliaro, Jane

Freeman, Andrew J; Vervoort, Stephin J; Michie, Jessica; Ramsbottom, Kelly M; Silke, John; Kearney, Conor J; Oliaro, Jane.

Afiliação

Freeman AJ; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.
Vervoort SJ; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic., Australia.
Michie J; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic., Australia.
Ramsbottom KM; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
Silke J; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.
Kearney CJ; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic., Australia.
Oliaro J; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.

EMBO Rep ; 22(11): e53391, 2021 11 04.

Article em En | MEDLINE | ID: mdl-34467615

Assuntos

Linfócitos T CD8-Positivos; Ubiquitina-Proteína Ligases; Apoptose/genética; Humanos; Interferon gama/farmacologia; Transdução de Sinais; Fator de Necrose Tumoral alfa/farmacologia; Ubiquitina-Proteína Ligases/metabolismo

Palavras-chave

CRISPR screen; HOIP; IFN-gamma; TNF; immunotherapy

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD8-Positivos / Ubiquitina-Proteína Ligases Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: EMBO Rep Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Austrália

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google