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Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Gonzalez-Del Pino, Gonzalo L; Li, Kunhua; Park, Eunyoung; Schmoker, Anna M; Ha, Byung Hak; Eck, Michael J.
Afiliação
  • Gonzalez-Del Pino GL; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215.
  • Li K; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
  • Park E; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215.
  • Schmoker AM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
  • Ha BH; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215.
  • Eck MJ; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Proc Natl Acad Sci U S A ; 118(36)2021 09 07.
Article em En | MEDLINE | ID: mdl-34470822
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MAP Quinase Quinase Quinases / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MAP Quinase Quinase Quinases / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article