Diet and exercise reduce pre-existing NASH and fibrosis and have additional beneficial effects on the vasculature, adipose tissue and skeletal muscle via organ-crosstalk.

van den Hoek, Anita M; de Jong, Jelle C B C; Worms, Nicole; van Nieuwkoop, Anita; Voskuilen, Marijke; Menke, Aswin L; Lek, Serene; Caspers, Martien P M; Verschuren, Lars; Kleemann, Robert

van den Hoek, Anita M; de Jong, Jelle C B C; Worms, Nicole; van Nieuwkoop, Anita; Voskuilen, Marijke; Menke, Aswin L; Lek, Serene; Caspers, Martien P M; Verschuren, Lars; Kleemann, Robert.

Afiliação

van den Hoek AM; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands. Electronic address: a.vandenhoek@tno.nl.
de Jong JCBC; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands; Human and Animal Physiology, Wageningen University, Wageningen, the Netherlands.
Worms N; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands.
van Nieuwkoop A; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands.
Voskuilen M; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands.
Menke AL; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands.
Lek S; Clinnovate Health UK Ltd, Glasgow, United Kingdom.
Caspers MPM; Department of Microbiology and Systems Biology, The Netherlands Organization for Applied Scientific Research (TNO), Zeist, the Netherlands.
Verschuren L; Department of Microbiology and Systems Biology, The Netherlands Organization for Applied Scientific Research (TNO), Zeist, the Netherlands.
Kleemann R; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands; Department of Vascular Surgery, Leiden University Medical Center, Leiden (LUMC), the Netherlands.

Metabolism ; 124: 154873, 2021 11.

Article em En | MEDLINE | ID: mdl-34478753

Assuntos

Dieta com Restrição de Gorduras; Cirrose Hepática/terapia; Hepatopatia Gordurosa não Alcoólica/terapia; Condicionamento Físico Animal/fisiologia; Receptores de LDL/genética; Transdução de Sinais/fisiologia; Tecido Adiposo Branco/metabolismo; Tecido Adiposo Branco/patologia; Animais; Aterosclerose/dietoterapia; Aterosclerose/genética; Aterosclerose/patologia; Aterosclerose/terapia; Dieta Hiperlipídica; Metabolismo dos Lipídeos; Fígado/metabolismo; Fígado/patologia; Cirrose Hepática/dietoterapia; Cirrose Hepática/patologia; Camundongos; Camundongos Knockout; Músculo Esquelético/metabolismo; Músculo Esquelético/patologia; Hepatopatia Gordurosa não Alcoólica/dietoterapia; Hepatopatia Gordurosa não Alcoólica/genética; Hepatopatia Gordurosa não Alcoólica/patologia; Receptores de LDL/metabolismo

Palavras-chave

Atherosclerosis; Fibrosis; Lifestyle interventions; Muscle-liver axis; NAFLD; WAT-liver axis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Receptores de LDL / Transdução de Sinais / Dieta com Restrição de Gorduras / Hepatopatia Gordurosa não Alcoólica / Cirrose Hepática Limite: Animals Idioma: En Revista: Metabolism Ano de publicação: 2021 Tipo de documento: Article

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