Discovery of 1,3,4-oxadiazole derivatives as potential antitumor agents inhibiting the programmed cell death-1/programmed cell death-ligand 1 interaction.

Fang, Lincheng; Tian, Jiping; Zhang, Kaixuan; Zhang, Xiaoyi; Liu, Yingqiao; Cheng, Zhibo; Zhou, Jinpei; Zhang, Huibin

Fang, Lincheng; Tian, Jiping; Zhang, Kaixuan; Zhang, Xiaoyi; Liu, Yingqiao; Cheng, Zhibo; Zhou, Jinpei; Zhang, Huibin.

Afiliação

Fang L; Center for Drug Discovery, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, PR China.
Tian J; Center for Drug Discovery, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, PR China.
Zhang K; Center for Drug Discovery, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, PR China.
Zhang X; Center for Drug Discovery, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, PR China.
Liu Y; College of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China.
Cheng Z; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.
Zhou J; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: jpzhou668@163.com.
Zhang H; Center for Drug Discovery, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: zhanghb80@163.com.

Bioorg Med Chem ; 46: 116370, 2021 09 15.

Article em En | MEDLINE | ID: mdl-34481337

Assuntos

Antígeno B7-H1/antagonistas & inibidores; Descoberta de Drogas; Oxidiazóis/farmacologia; Receptor de Morte Celular Programada 1/antagonistas & inibidores; Animais; Antígeno B7-H1/metabolismo; Relação Dose-Resposta a Droga; Humanos; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Estrutura Molecular; Oxidiazóis/síntese química; Oxidiazóis/química; Receptor de Morte Celular Programada 1/metabolismo; Ligação Proteica/efeitos dos fármacos; Relação Estrutura-Atividade

Palavras-chave

Molecular docking; PD-1/PD-L1; Small molecule inhibitor; Tumor immunity

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxidiazóis / Descoberta de Drogas / Antígeno B7-H1 / Receptor de Morte Celular Programada 1 Limite: Animals / Humans / Male Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google