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Cellular model system to dissect the isoform-selectivity of Akt inhibitors.
Quambusch, Lena; Depta, Laura; Landel, Ina; Lubeck, Melissa; Kirschner, Tonia; Nabert, Jonas; Uhlenbrock, Niklas; Weisner, Jörn; Kostka, Michael; Levy, Laura M; Schultz-Fademrecht, Carsten; Glanemann, Franziska; Althoff, Kristina; Müller, Matthias P; Siveke, Jens T; Rauh, Daniel.
Afiliação
  • Quambusch L; Faculty of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
  • Depta L; Faculty of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
  • Landel I; Faculty of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
  • Lubeck M; Faculty of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
  • Kirschner T; Faculty of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
  • Nabert J; Faculty of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
  • Uhlenbrock N; Faculty of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
  • Weisner J; Faculty of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
  • Kostka M; Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Dortmund, Germany.
  • Levy LM; Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Dortmund, Germany.
  • Schultz-Fademrecht C; Lead Discovery Center GmbH, Dortmund, Germany.
  • Glanemann F; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Medicine Essen, Essen, Germany.
  • Althoff K; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen, Heidelberg, Germany.
  • Müller MP; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Medicine Essen, Essen, Germany.
  • Siveke JT; Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen, Heidelberg, Germany.
  • Rauh D; Faculty of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
Nat Commun ; 12(1): 5297, 2021 09 06.
Article em En | MEDLINE | ID: mdl-34489430
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-akt / Bibliotecas de Moléculas Pequenas / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-akt / Bibliotecas de Moléculas Pequenas / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha