Toxicity of carbon ion radiotherapy and immune checkpoint inhibitors in advanced melanoma.

Cavalieri, Stefano; Ronchi, Sara; Barcellini, Amelia; Bonora, Maria; Vischioni, Barbara; Vitolo, Viviana; Villa, Riccardo; Del Vecchio, Michele; Licitra, Lisa; Orlandi, Ester

Cavalieri, Stefano; Ronchi, Sara; Barcellini, Amelia; Bonora, Maria; Vischioni, Barbara; Vitolo, Viviana; Villa, Riccardo; Del Vecchio, Michele; Licitra, Lisa; Orlandi, Ester.

Afiliação

Cavalieri S; Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Ronchi S; Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy. Electronic address: sara.ronchi@cnao.it.
Barcellini A; Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy.
Bonora M; Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy.
Vischioni B; Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy.
Vitolo V; Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy.
Villa R; Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy.
Del Vecchio M; Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Licitra L; Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Italy.
Orlandi E; Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy.

Radiother Oncol ; 164: 1-5, 2021 11.

Article em En | MEDLINE | ID: mdl-34506831

ABSTRACT

ABSTRACT

We analyzed CTCAE adverse events of sequential Carbon Ion radiotherapy (CIRT) and immune checkpoint inhibitors (ICIs) in advanced melanoma patients. The frequencies of early and late adverse events (AEs) were 100% and 82% of patients, respectively. The frequency of G3+ AEs was in line with the literature.

Assuntos

Radioterapia com Íons Pesados; Melanoma; Radioterapia com Íons Pesados/efeitos adversos; Humanos; Inibidores de Checkpoint Imunológico; Melanoma/tratamento farmacológico

Palavras-chave

Adverse events; Carbon ion radiotherapy; Carbon ion radiotherapy and immunotherapy combination; Immune checkpoint inhibitors; Mucosal melanoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radioterapia com Íons Pesados / Melanoma Limite: Humans Idioma: En Revista: Radiother Oncol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália

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