In vivo and in vitro comparison of three astilbin encapsulated zein nanoparticles with different outer shells.
Food Funct
; 12(20): 9784-9792, 2021 Oct 19.
Article
em En
| MEDLINE
| ID: mdl-34533153
ABSTRACT
Three shell materials, lecithin (ZNP-L), chitosan (ZNP-CH) and sodium caseinate (ZNP-SC), were used to prepare core-shell zein nanoparticles. Astilbin was encapsulated as a model flavonoid to compare the influence of the shell materials on zein nanoparticles both in vitro and in vivo. The particle size was moderately increased by lecithin and sodium caseinate, but notably increased by chitosan. All the shell materials provided good redispersibility for the nanoparticles and significantly improved the colloidal stability. Chitosan and sodium caseinate significantly delayed and decreased the feces excretion of astilbin in rats, while lecithin exhibited a very weak effect. The results may be attributed to the difference in mucoadhesive properties between the shell materials. As a consequence, the bioavailability values of astilbin in rats were 18.2, 9.3 and 1.89 times increased through ZNP-CH, ZNP-SC and ZNP-L compared with that of free astilbin, respectively.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
/
Flavonóis
/
Nanocápsulas
Limite:
Animals
Idioma:
En
Revista:
Food Funct
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China