Bitter Taste Receptor T2R14 Modulates Gram-Positive Bacterial Internalization and Survival in Gingival Epithelial Cells.

Medapati, Manoj Reddy; Bhagirath, Anjali Yadav; Singh, Nisha; Schroth, Robert J; Bhullar, Rajinder P; Duan, Kangmin; Chelikani, Prashen

Medapati, Manoj Reddy; Bhagirath, Anjali Yadav; Singh, Nisha; Schroth, Robert J; Bhullar, Rajinder P; Duan, Kangmin; Chelikani, Prashen.

Afiliação

Medapati MR; Manitoba Chemosensory Biology Research Group, Department of Oral Biology, Rady Faculty of Health Sciences, Dr. Gerald Niznick College of Dentistry, University of Manitoba, 780 Bannatyne Avenue, Winnipeg, MB R3E 0W2, Canada.
Bhagirath AY; Manitoba Chemosensory Biology Research Group, Department of Oral Biology, Rady Faculty of Health Sciences, Dr. Gerald Niznick College of Dentistry, University of Manitoba, 780 Bannatyne Avenue, Winnipeg, MB R3E 0W2, Canada.
Singh N; Children's Hospital Research Institute of Manitoba (CHRIM), University of Manitoba, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada.
Schroth RJ; Manitoba Chemosensory Biology Research Group, Department of Oral Biology, Rady Faculty of Health Sciences, Dr. Gerald Niznick College of Dentistry, University of Manitoba, 780 Bannatyne Avenue, Winnipeg, MB R3E 0W2, Canada.
Bhullar RP; Manitoba Chemosensory Biology Research Group, Department of Oral Biology, Rady Faculty of Health Sciences, Dr. Gerald Niznick College of Dentistry, University of Manitoba, 780 Bannatyne Avenue, Winnipeg, MB R3E 0W2, Canada.
Duan K; Children's Hospital Research Institute of Manitoba (CHRIM), University of Manitoba, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada.
Chelikani P; Department of Preventive Dental Sciences, Rady Faculty of Health Sciences, Dr. Gerald Niznick College of Dentistry, University of Manitoba, 780 Bannatyne Avenue, Winnipeg, MB R3E 0W2, Canada.

Int J Mol Sci ; 22(18)2021 Sep 14.

Article em En | MEDLINE | ID: mdl-34576085

Assuntos

Endocitose; Células Epiteliais/metabolismo; Gengiva/citologia; Bactérias Gram-Positivas/metabolismo; Viabilidade Microbiana; Receptores Acoplados a Proteínas G/metabolismo; Paladar; Actinas/metabolismo; Linhagem Celular; Células Epiteliais/ultraestrutura; Humanos; Interleucina-8/metabolismo; Modelos Biológicos; Nitratos/metabolismo; Nitritos/metabolismo; Staphylococcus aureus/metabolismo; Streptococcus mutans/metabolismo; beta-Defensinas/metabolismo; Quinases Ativadas por p21/metabolismo; Proteínas rac1 de Ligação ao GTP/metabolismo

Palavras-chave

G-protein-coupled receptor (GPCR); Gram-positive bacteria; bitter taste receptor (T2R); gingival epithelial cell; host-microbe interaction; innate immunity; internalization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paladar / Receptores Acoplados a Proteínas G / Endocitose / Células Epiteliais / Viabilidade Microbiana / Gengiva / Bactérias Gram-Positivas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá

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