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An update on the safety of insulin-GLP-1 receptor agonist combinations in type 2 diabetes mellitus.
Novodvorský, Peter; Haluzík, Martin.
Afiliação
  • Novodvorský P; Diabetes Centre, Institute for Clinical and Experimental Medicine (Ikem), Prague, Czech Republic.
  • Haluzík M; Department of Oncology & Metabolism, University of Sheffield, Sheffield, UK.
Expert Opin Drug Saf ; 21(3): 349-361, 2022 Mar.
Article em En | MEDLINE | ID: mdl-34641742
ABSTRACT

INTRODUCTION:

Recent development of novel antidiabetic drugs with proven cardiovascular (CV) and renal benefit and positive effect on body weight enable to take a more complex approach toward the management of type 2 diabetes mellitus (T2DM). Fixed-ratio combinations of insulin-GLP-1 receptor agonist (FRC) utilize complementary mechanisms of action of their individual components and address multiple pathologies linked with T2DM at the same time. AREAS COVERED There are currently three FRCs on the market iGlarLixi (glargine and lixisenatide in 2 different formulations) and IDegLira (degludec and liraglutide). We provide an up-to-date review on the rationale for the use of FRCs and their current position in the management of T2DM. We discuss the available evidence from randomized controlled trials, post hoc analyses, indirect comparative studies and real-world data on their effect on glycemic control, risk of hypoglycemia, body weight, CV safety, and their safety profile. EXPERT OPINION FRCs represent an efficacious option for treatment intensification from basal insulin or even the first insulin-based therapy in T2DM. Their excellent glucose-lowering efficacy is complemented with lower risk of hypoglycemia in comparison to basal insulin, neutral effect on body weight and the lower risk of gastrointestinal adverse effects in comparison to GLP-1 receptor agonists.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Hipoglicemia Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Revista: Expert Opin Drug Saf Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: República Tcheca

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Hipoglicemia Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Revista: Expert Opin Drug Saf Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: República Tcheca