Lipotoxicity: a driver of heart failure with preserved ejection fraction?
Clin Sci (Lond)
; 135(19): 2265-2283, 2021 10 15.
Article
em En
| MEDLINE
| ID: mdl-34643676
ABSTRACT
Heart failure with preserved ejection fraction (HFpEF) is a growing public health concern, with rising incidence alongside high morbidity and mortality. However, the pathophysiology of HFpEF is not yet fully understood. The association between HFpEF and the metabolic syndrome (MetS) suggests that dysregulated lipid metabolism could drive diastolic dysfunction and subsequent HFpEF. Herein we summarise recent advances regarding the pathogenesis of HFpEF in the context of MetS, with a focus on impaired lipid handling, myocardial lipid accumulation and subsequent lipotoxicity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Volume Sistólico
/
Função Ventricular Esquerda
/
Síndrome Metabólica
/
Metabolismo dos Lipídeos
/
Insuficiência Cardíaca
/
Miocárdio
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Clin Sci (Lond)
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Reino Unido